Vitreous levels of interleukin 6 and 10 in patients with primary intraocular lymphoma.

Accession number;00A0403345
Title;Vitreous levels of interleukin 6 and 10 in patients with primary intraocular lymphoma.
Author; MASAOKA NORIO (Kochi Med. Sch.) MATSUSHITA KUMIKO (Kochi Med. Sch.) HASHIDA MASATSUGU (Kochi Med. Sch.) HAYASHI NOBUAKI (Kochi Med. Sch.)
Journal Title;Japanese Journal of Clinical Ophthalmology
Journal Code:Z0515B
ISSN:0370-5579
VOL.54;NO.3;PAGE.357-360(2000)
Figure&Table&Reference;TBL.2, REF.13
Pub. Country;Japan
Language;Japanese
Abstract;We measured the vitreous level of interleukins (IL) in 4 patients with primary intraocular lymphoma and in 3 patients with uveitis. IL-10 was measured using an enzyme-linked immunosorbent assay (ELISA) and IL-6 using a chemiluminescent enzyme immunoassay (CLEIA). The levels of IL-10 were higher than IL-6 in all the 4 patients with primary intraocular lymphoma and in none of 3 patients with uveitis. Two patients of intraocular lymphoma with eventual involvement of the central nervous system showed higher values of IL-10 than the other 2 without intracranial involvement. The findings show that the ratio of intravitreal IL-10 to IL-6 may serve as a guide in the diagnosis of malignant lymphoma. (author abst.)