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Positive Allosterism Designed on Dynamic Supramolecular Scaffolds: Toward Switching and Amplification of Guest Affinity and Selectivity.

Accession number;02A0304357

Title;Positive Allosterism Designed on Dynamic Supramolecular Scaffolds: Toward Switching and Amplification of Guest Affinity and Selectivity.

Author; TAKEUCHI MASAYUKI (Kyushu Univ., Grad. Sch.) IKEDA MASATO (Kyushu Univ., Grad. Sch.) SUGASAKI ATSUSHI (Kyushu Univ., Grad. Sch.) SHINKAI SEIJI (Kyushu Univ., Grad. Sch.)

Journal Title;Abstracts. Symposium on Biofunctional Chemistry

Journal Code:L0836A

ISSN:

VOL.16th;NO.;PAGE.2-3(2001)

Figure&Table&Reference;

Pub. Country;Japan

Language;Japanese

Abstract;The biomimetic design of allosteric systems is of great significance because they are readily applicable to the efficient regulation of drug release, catalytic reactions, and information transduction. Especially, the positive homotoropic allosteric system is useful as a unique tool for amplifying and transforming weak chemical or physical signals into another forms and for constructing novel sensory systems with higher affinity and/or greater selectivity towards analytes. Here we report the design scheme for positive homotropic allosterism and its application to biologically important saccharide sensing system. (author abst.)

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