Development of wireless information processing circuits on artificial cell-membrane.
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Accession number;02A0304360
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| Title;Development of wireless information processing circuits on artificial cell-membrane. |
| Author;
SASAKI YOSHIHIRO
(Advanced Inst. Sci. and Technol., Nara)
TIAN W
(Advanced Inst. Sci. and Technol., Nara)
ARIGA KATSUHIKO
(Advanced Inst. Sci. and Technol., Nara)
KIKUCHI JUN'ICHI
(Advanced Inst. Sci. and Technol., Nara)
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Journal Title;Abstracts. Symposium on Biofunctional Chemistry
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Journal Code:L0836A
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ISSN:
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VOL.16th;NO.;PAGE.8-9(2001)
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| Figure&Table&Reference; |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Natural signal transduction system is regarded as a highly sophisticated information processing device achieved through indirect signal transmission among various components such as receptors, mediators and effector enzymes. Our attentions have been focused to develop the artificial signal transduction system on synthetic membranes, in which a synthetic receptor, an effector enzyme and a mediator, are functionally connected one another. In such artificial system, the binding of an external chemical signal to the receptor can switch on the enzymatic activity in collaboration with appropriate transmitter species. In this paper, we are to report the construction of a supramolecular device which acts as an AND-type logic gate on lipid bilayer vesicles. The hybrid assembly was formed with a combination of the photo- and chemo-responsive receptor, Cu(II), LDH, and DMPC as a receptor, a transmitter, an effector, and a membrane-forming lipid, respectively. For 1-hydroxy-2-naphthaldehyde HNA as an external signal, reversible activation and inactivation of the LDH was achieved through transfer of Cu(II) ions between the receptor-ligand complex and the LDH when the receptor having shorter spacer was employed. In addition, it became clear that the spacer length between the molecular recognition part and the photoresponsive moiety is sensitive to the signal transmission efficiency. (author abst.) |
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