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Accession number;02A0304366
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| Title;Preparation of Artificial Enzyme by Insertion of Metal Complex to Apo-Myoglobin. |
| Author;
OHASHI MASATAKA
(Graduate Univ. Advances Studies)
UENO TAKAFUMI
(Togobaiosaiensuse)
FUJII HIROSHI
(Graduate Univ. Advances Studies)
WATANABE YOSHIHITO
(Graduate Univ. Advances Studies)
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Journal Title;Abstracts. Symposium on Biofunctional Chemistry
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Journal Code:L0836A
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ISSN:
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VOL.16th;NO.;PAGE.20-21(2001)
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| Figure&Table&Reference; |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Preparation of artificial metalloenzymes is one of the most interesting subject of bloinorganic chemistry. We have prepared artificial enzymes by inserting the MnIII(salophen) to apo-myoglobin mutants. Our designed metalloenzymes, especially MnIII(salophen)/H64D/A71G, catalyze asymmetric oxidation of thioanisole, though apo- and holo-Mbs show little enantio selectivity. The results suggest that designed protein/metal complexes are potent catalysts for enantioselective oxidation. (author abst.) |
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