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Accession number;02A0304376
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| Title;Self-Assembling Properties of Peptide Derivatives Composed of Urea Spacer. |
| Author;
MORIUCHI TOSHIYUKI
(Osaka Univ., Grad. Sch.)
TAMURA TAKASHI
(Osaka Univ., Grad. Sch.)
HIRAO TOSHIKAZU
(Osaka Univ., Grad. Sch.)
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Journal Title;Abstracts. Symposium on Biofunctional Chemistry
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Journal Code:L0836A
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ISSN:
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VOL.16th;NO.;PAGE.40-41(2001)
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| Figure&Table&Reference; |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Urea tetrapeptide derivatives composed of two dipeptide chains (-L-Ala-L-Pro-NHPy) have been synthesized to form stable hydrogen-bonded duplexes in both solid and solution states, which were investigated by 1H-NMR, FT-IR and X-ray crystallographic analyses. The single-crystal X-ray structure determination of the urea tetrapeptide derivative 1 composed of two -L-Ala-L-Pro-NHPy revealed that two molecules of 1 form a hydrogen-bonded duplex by six intermolecular hydrogen bonds. Proton magnetic resonance nuclear Overhauser effect(NOE) study of 1 indicates the similar hydrogen-bonded duplex even in solution. The urea tetrapeptide derivative composed of two dipeptide chains (-L-Ala-L-Pro-NHCH2Pyr) exhibited both monomer and eximer emissions in the fluorescence spectra, supporting the formation of a duplex structure. Such hydrogen-bonded duplexes were not organized in the case of the urea tetrapeptide derivative composed of two dipeptide chains (-L-Ala-L-Pro-OEt) and the urea dipeptide derivative composed of only one dipeptide chains (-L-Ala-L-Pro-NHCH2Pyr), suggesting that the NH adjacent to the pyridyl moiety in each side and the reasonable sequence of hydrogen-bonding sites are considered to be a crucial factor for the formation of a duplex. (author abst.) |
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