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Accession number;02A0304403
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| Title;Photodynamic therapy for cancer cells using metal-halide lamp. |
| Author;
KOSOBE TOSHIYUKI
(Toin Univ. of Yokohama, Fac. of Eng.)
TOKUOKA YOSHIKAZU
(Toin'yokohamadai Sentan'iyokose)
KIMURA MAKOTO
(Ushio Inc.)
WAKUI SHIRO
(Toin'yokohamadai Sentan'iyokose)
KAWASHIMA NORIMICHI
(Toin Univ. of Yokohama, Fac. of Eng.)
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Journal Title;Abstracts. Symposium on Biofunctional Chemistry
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Journal Code:L0836A
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ISSN:
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VOL.16th;NO.;PAGE.94-95(2001)
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| Figure&Table&Reference; |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Photodynamic therapy(PDT) for cancer cell of mouse (EL-4) was carried out using metal-halide lamps, and the effect of the lamps on the PDT was investigated. 5-aminolebrinic acid (5-ALA) was used as a photosensitizing agent. Tumoricidal ratio of EL-4 increased with the total irradiation energy at 630-670nm wavelength and reached almost 90% at about 100J/cm2 of the total irradiation energy. Moreover, the tumoricidal ratio with UV lamp at 400-410nm was greater than that with visible light of 630-670um. In addition, the tumoricidal ratio with intermittent irradiation was found greater than that with continuous irradiation at the same total irradiation energy of light. On the basis of these experimental results, metal-halide lamps are considered to be effective for PDT of tumor tissues. (author abst.) |
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