Efficacy and Safety of an Aqueous Extract from Mycoleptodonoides aitchisonii in the Long-term Administration.

Accession number;02A0207605
Title;Efficacy and Safety of an Aqueous Extract from Mycoleptodonoides aitchisonii in the Long-term Administration.
Author; TSUCHIDA TAKASHI (Hoyokai Isogochuo・noshinkeigekabyoin Kenkokanrise) MASHIKO KENTO (Mashikokai Kodama Chuo Byoin) OSADA HIDEYUKI (Sentorarubyoin) SATO TAKU (Kirimbiru Oyokaise)
Journal Title;Japanese Pharmacology & Therapeutics
Journal Code:Z0947A
ISSN:0386-3603
VOL.30;NO.1;PAGE.31-36(2002)
Figure&Table&Reference;FIG.2, TBL.4, REF.4
Pub. Country;Japan
Language;Japanese
Abstract;In the preceding report, we examined the effect of an aqueous extract from Mycoleptodonoides aitchisonii on adults with mildly hypertension (systolic blood pressure 145.9.+-.6.5mmHg, diastolic blood pressure 91.0.+-.4.5mmHg, average age 46.5.+-.9.0 years old, 60 people) by a double blind method using a placebo and observed a significant hypotensive effect in the groups administered with an aqueous extract from Mycoleptodonoides aitchisonii at 0.5g to 1.0g/day for 4 weeks in comparison with that administered placebo. In the present study, a significant hypotensive effect was observed in the groups administered with an aqueous extract from Mycoleptodonoides aitchisonii at 1.0g/day for 12 weeks. Furthermore, subjective symptom, objective symptom and all other side effects were not observed in all subjects. From these results, it was concluded that an aqueous extract from Mycoleptodonoides aitchisonii improved hypertension of the person, without showing subjective symptoms and affecting hematological and urinalytical parameters in the long-term administration. (author abst.)