Phase I Clinical Study of SS320A. (5). Drug Interaction with Theophylline and Examination on Enantiomer of SS320A.
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Accession number;02A0208992
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| Title;Phase I Clinical Study of SS320A. (5). Drug Interaction with Theophylline and Examination on Enantiomer of SS320A. |
| Author;
SHIBATA HITOSHI
(Kitasatoken Baioiatorikkuse)
YAFUNE AKIFUMI
(Kitasatoken Baioiatorikkuse)
OIKAWA TAKAYUKI
(SS Pharm. Co., Ltd., Cent. Res. Lab.)
YOKOYAMA TOSHIO
(SS Pharm. Co., Ltd., Cent. Res. Lab.)
KURAISHI TADAYUKI
(Esuesuseiyaku Shin'yakukaihatsurinshobu)
NISHIMINE HIDEO
(Yoshitomi Pharm. Ind., Ltd., Chem. Res. Lab.)
OKA TAICHI
(Yoshitomiseiyaku Rinshokaihatsudaiichibu)
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Journal Title;Journal of Clinical Therapeutics & Medicines
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Journal Code:Y0906A
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ISSN:0910-8211
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VOL.18;NO.1;PAGE.53-66(2002)
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| Figure&Table&Reference;FIG.3, TBL.8, REF.15 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;SS320A of 400 mg, or theophylline of 200 mg, or SS320A of 400 mg and theophyline of 200 mg concomitantly was orally given to healthy adult male volunteers under fasting. 1) Plasma levels of SS320A and theophylline in combined administration changed in the same manner as those in monotherapy, confirming no drug interaction. 2) SS320A was not converted to S body, an enantiomer, in human body. 3) For safety profile, no clinically significant findings were observed in subjective symptoms or laboratory data. (author abst.) |
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