Clinical Trial of SS320A. The Studies on Scanning Electron Microscopy of Sputum.
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Accession number;02A0208999
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| Title;Clinical Trial of SS320A. The Studies on Scanning Electron Microscopy of Sputum. |
| Author;
NAGAOKA SHIGERU
(Japan Res. Inst. Sputum)
MURATA MISAO
(SS Pharm. Co., Ltd., Cent. Res. Lab.)
YAMANAKA EIICHI
(Inst. of Whole Body Metab.)
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Journal Title;Journal of Clinical Therapeutics & Medicines
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Journal Code:Y0906A
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ISSN:0910-8211
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VOL.18;NO.1;PAGE.233-243(2002)
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| Figure&Table&Reference;FIG.4, TBL.5, REF.10 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;To 20 patients with chronic respiratory diseases complaining of the difficulty in expectoration of sputum, SS320A was given at a daily dose of 1.2g (divided into 3) for 2 weeks, and the sputa before and after treatment observed by scanning electron microscope and investigated the relationship of the changes in clinical symptoms, physico-chemical properties of sputum and the transport velocity by cilia of frog palate mucosae. The images observed by electron microscope were analyzed by an image analyzer, defined the open space of mesh structure of sputum as the black area, and measured the black area. As the results, the ratio of black area after administration of SS320A significantly increased from 34.54 .+-. 1.99 to 39.85 .+-. 1.72% (p = 0.003). In 14 of 17 cases who showed increases in the ratio of black area, marked improvement in subjective symptoms was observed. Further, out of 13 cases who showed increases in both of the ratio of black area and the transport velocity by cilia of frog palate mucosae, 11 cases showed marked improvement in subjective symptoms. From the above results, the relationship was suggested among a increase in the open space of mesh structure of sputum, the transport velocity by cilia of frog palate mucosae and the improvement in subjective symptoms related to the difficulty in expectoration of sputum. The examination of mesh structure of sputum by scanning electron microscope seems possible to be used as an objective marker for the efficacy evaluation of mucoactive agent. (author abst.) |
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