Inhibition of enteropeptidase by antitrypsin drugs.
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Accession number;02A0266681
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| Title;Inhibition of enteropeptidase by antitrypsin drugs. |
| Author;
MATSUSHIMA M
(Univ. Tokyo, Tokyo, Jpn)
YAHAGI N
(Univ. Tokyo, Tokyo, Jpn)
ICHINOSE M
(Univ. Tokyo, Tokyo, Jpn)
MIKI K
(Univ. Tokyo, Tokyo, Jpn)
OMATA M
(Univ. Tokyo, Tokyo, Jpn)
INOUE H
(Univ. Tokyo, Tokyo, Jpn)
TAKAHASHI T
(Univ. Tokyo, Tokyo, Jpn)
TAKAHASHI K
(Univ. Tokyo, Tokyo, Jpn)
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Journal Title;Biomed Res
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Journal Code:Z0236B
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ISSN:0388-6107
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VOL.22;NO.5;PAGE.257-260(2001)
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| Figure&Table&Reference;FIG.2, REF.16 |
| Pub. Country;Japan |
| Language;English |
| Abstract;We have investigated the inhibitory effects on porcine enteropeptidase of some typical synthetic amidino- and guanidino-compounds developed as antitrypsin drugs. The results indicated that enteropeptidase is inhibited by these compounds almost as strongly as trypsin; their IC50 values were in the range of 0.008-4.MU.M, which were much lower than that of the well-known trypsin/enteropeptidase inhibitor benzamidine. (author abst.) |
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