Suppression of IgE Synthesis against Cow's Milk Protein in Bottle-fed Infants with Atopic Dermatitis.
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Accession number;02A0298021
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| Title;Suppression of IgE Synthesis against Cow's Milk Protein in Bottle-fed Infants with Atopic Dermatitis. |
| Author;
SEKINE YUJI
(Shizuokakenkodomobyoin Kansenmen'ekiarerugika)
KIMURA MITSUAKI
(Shizuokakenkodomobyoin Kansenmen'ekiarerugika)
YAMAIDE AKIKO
(Shizuokakenkodomobyoin Kansenmen'ekiarerugika)
TSURUTA SATORU
(Shizuokakenkodomobyoin Kansenmen'ekiarerugika)
OKAFUJI IKUO
(Shizuokakenkodomobyoin Kansenmen'ekiarerugika)
YOSHIDA TAKAMI
(Shizuokakenkodomobyoin Kansenmen'ekiarerugika)
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Journal Title;Journal of the Japan Pediatric Society
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Journal Code:F0896A
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ISSN:0001-6543
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VOL.106;NO.3;PAGE.360-367(2002)
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| Figure&Table&Reference;FIG.5, TBL.3, REF.39 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;A small amount of food proteins such as egg white or cow's milk transferred through the placenta or via breast milk is thought to be enough to induce IgE synthesis in infants. On the other hand, oral ingestion of proteins has been shown to induce immunological tolerance which abolishes or suppresses immune reactions against ingested proteins. To clarify the actual effect of food on food-specific IgE synthesis in early infancy, we analyzed the difference in the level of IgE antibody specific to cow's milk (measured by IgE-RAST) between breast- and bottle-fed infants with atopic dermatitis. One hundred forty-eight subjects were divided into three groups according to the mode of feeding before the time of the examination: 75 infants were breast-fed, 32 bottle-fed and 41 fed by the mixed mode. There were no signifiant differences among these three groups in the sex, months of age of exmanination (breast 5.89.+-.2.64 months, bottle 6.16.+-.2.27, mixed 6.27.+-.2.24) and the incidence of positive family history of allergy. The geomeric mean of cow's milk-specific IgE antibody was 0.35UA/ml in bottle-fed infants, which was significantly lower than that in breast-fed ones (2.40UA/ml, p<0.005) and comparable to that in those fed by the mixed mode (0.40UA/ml). Although the difference was not as distinct as in the case of cow's milk, the level of egg white-specific IgE antibody (breast 10.2, bottle 4.47, mixed 3.89UA/ml) as well as serum IgE (breast 131.8, bottle 51.3, mixed 60.3IU/ml) was significantly lower in bottle-fed infants and those fed by the mixed mode than in breast-fed ones (p<0.01-0.02). These findings suggests that ingestion of artificial formula made of cow's milk strongly suppresses IgE synthesis against cow's milk proteins and less potently against other foods by inducing immunological tolerance. (author abst.) |
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