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Accession number;02A0298025
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| Title;Serum KL-6 and SP-D in Acute-phase of Neonates with Meconium Aspiration Syndrome. |
| Author;
TAKAMI TAKESHI
(Tokyo Medical Univ., JPN)
TAKEI YUKITO
(Tokyo Medical Univ., JPN)
TACHIBANA MAKI
(Tokyo Medical Univ., JPN)
KUMADA ATSUSHI
(Tokyo Medical Univ., JPN)
MIYAJIMA TASUKU
(Tokyo Medical Univ., JPN)
HOSHIKA AKINORI
(Tokyo Medical Univ., JPN)
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Journal Title;Journal of the Japan Pediatric Society
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Journal Code:F0896A
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ISSN:0001-6543
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VOL.106;NO.3;PAGE.383-388(2002)
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| Figure&Table&Reference;FIG.3, TBL.2, REF.26 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The serum markers KL-6 and SP-D have been reported to be valuable indicators of the disease activity of interstitial pneumonia in adults. We measured them simultaneously in neonates with meconium aspiration syndrome(MAS). Serum samples were collected within 24 hours after birth both in full-term control neotates without respiratory diseases (n=50) and neonates with MAS (n=50). The mean value of serum KL-6 in neonates with MAS (218.2.+-.18.5U/ml) was significantly higher than in control neonates (161.1.+-.9.1U/ml). There were no statistically significant differences of the mean value ot serum SP-D between control neonates (90.8.+-.8.5ng/ml) and the neonates with MAS (66.9.+-.10.2ng/ml). The levels of serum KL-6 were found to be increased significantly on day five and 10 after birth in neonates with severe MAS (n=7) controlled by mechanical ventilation compared to control neonates (n=10) and in neonates with mild MAS (n=7), but the levels of serum SP-D did not show the significant differences. Our findings suggest that high serum levels of KL-6 show activity of interstitial lung disease and it could be a useful tool to evaluate the severity of lung damage in MAS. (author abst.) |
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