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Accession number;02A0169400
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| Title;L-myc Genotype is Associated with Different Susceptibility to Lung Cancer in Smokers. |
| Author;
KUMIMOTO H
(Aichi Cancer Center Res. Inst., Aichi)
HAMAJIMA N
(Aichi Cancer Center Res. Inst., Aichi)
NISHIMOTO Y
(Aichi Cancer Center Res. Inst., Aichi)
MATSUO K
(Aichi Cancer Center Res. Inst., Aichi)
SHINODA M
(Aichi Cancer Center Hospital, Aichi)
HATOOKA S
(Aichi Cancer Center Hospital, Aichi)
ISHIZAKI K
(Aichi Cancer Center Res. Inst., Aichi)
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Journal Title;Jpn J Cancer Res
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Journal Code:F0633A
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ISSN:0910-5050
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VOL.93;NO.1;PAGE.1-5(2002)
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| Figure&Table&Reference;TBL.5, REF.18 |
| Pub. Country;Japan |
| Language;English |
| Abstract;We have shown that L-myc genotype is associated with the risk of esophageal cancer from smoking and heavy drinking. In this study, we have analyzed the relationship between the L-myc genotypes and lung cancer risk from smoking in 191 Japanese lung-cancer patients and 241 non-cancer controls. The odds ratios (ORs) were markedly higher in SS and LS genotypes than in LL genotype; age-sex-adjusted ORs were 3.19, 2.30 and 0.92, respectively. This result suggests that the L-myc polymorphism may affect the induction of lung cancer by smoking. The OR for smoking in SS-geno-type patients diagnosed within 2 years was higher than that in other SS patients, suggesting that smoking-related lung cancer in SS genotype might exhibit a poorer prognosis. (author abst.) |
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