Anti-tumor Effect of Chemically Synthesized Sulfolipids Based on Sea Urchin's Natural Sulfonoquinovosylmonoacylglycerols.
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Accession number;02A0169411
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| Title;Anti-tumor Effect of Chemically Synthesized Sulfolipids Based on Sea Urchin's Natural Sulfonoquinovosylmonoacylglycerols. |
| Author;
SAHARA H
(Sapporo Medical Univ. School Of Medicine, Hokkaido)
HANASHIMA S
(Sci. Univ. Tokyo, Chiba)
YAMAZAKI T
(Sci. Univ. Tokyo, Chiba)
TAKAHASHI S
(Inst. Physical And Chemical Res., Saitama)
SUGAWARA F
(Sci. Univ. Tokyo, Chiba)
OHTANI S
(Sapporo Medical Univ. School Of Medicine, Hokkaido)
ISHIKAWA M
(Sapporo Medical Univ. School Of Medicine, Hokkaido)
MIZUSHIMA Y
(Sci. Univ. Tokyo, Chiba)
TAKAHASHI N
(Sapporo Medical Univ. School Of Medicine, Hokkaido)
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Journal Title;Jpn J Cancer Res
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Journal Code:F0633A
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ISSN:0910-5050
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VOL.93;NO.1;PAGE.85-92(2002)
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| Figure&Table&Reference;FIG.5, REF.19 |
| Pub. Country;Japan |
| Language;English |
| Abstract;We recently reported that 3'-sulfonoquinovosyl-1'-monoacylglycerol (designated A-5) extracted from sea urchin intestine was effective in suppressing the growth of solid tumors. Although the major fatty acid component of A-5 was a saturated C16 acid, there were five other fatty acids, 14:0, 18:0, 14:1, 16:1, and 18:1, which constitute minor components of A-5. Therefore, it remains unclear as to which of these six fatty acid components of A-5 has the anti-tumor effect. In this study, we synthesized sulfolipids each containing only one of these six fatty acids and tested their cytotoxicity against tumor cells and in vivo anti-tumor effects on nude-mice bearing solid tumors of human lung adenocarcinoma cell line A-549. The IC50 values of all products against tumor cells were more than 10-5 M, suggesting weak cytotoxic activity compared with other chemotherapeutic compounds for cancer. On the other hand, in vivo anti-tumor assay showed that sulfoquinovosylmonoacylglycerols (SQMG) composed of 14:1 and 18:1 (designated SQMG(14:1) and SQMG(18:1), respectively) were significantly effective in suppressing the growth of solid tumors. Our data suggested that these two SQMGs had a substantial anti-tumor effect in vivo, and they are of interest as candidate drugs for anti-cancer treatment. (author abst.) |
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