Effect of Functional Magnetic Particles on Radiofrequency Capacitive Heating: An in vivo Study.
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Accession number;02A0169413
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| Title;Effect of Functional Magnetic Particles on Radiofrequency Capacitive Heating: An in vivo Study. |
| Author;
SHINKAI M
(Nagoya Univ., Nagoya)
UEDA K
(Nagoya City Univ. Medical School, Nagoya)
OHTSU S
(Nagoya Univ., Nagoya)
HONDA H
(Nagoya Univ., Nagoya)
KOHRI K
(Nagoya City Univ. Medical School, Nagoya)
KOBAYASHI T
(Nagoya Univ., Nagoya)
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Journal Title;Jpn J Cancer Res
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Journal Code:F0633A
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ISSN:0910-5050
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VOL.93;NO.1;PAGE.103-108(2002)
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| Figure&Table&Reference;FIG.4, TBL.1, REF.16 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Specific heating of magnetic particles in radiofrequency (RF) capacitive hyperthermia and its hyperthermic effect were investigated in an in vivo study. Magnetite cationic liposomes (MCLs) were injected into a rat tumor on the femur and 8 MHz-RF capacitive heating was applied to the rat under 'mild heating' conditions. Although the input power of RF capacitive heating was low under the same power conditions, the MCLs-injected tumor was heated over 43.DEG.C., whereas it was only heated to 41.DEG.C. in the case of the rats not injected with MCLs. A necrotic area in the tumor was observed in the heated rats. From the results of histological observation of the removed tissue, the necrotic area in the MCLs-injected tumor was wider than that in MCLs-free tumor. Complete tumor suppression was observed in 71% (5/7) of MCLs-injected rats, and the hyperthermic effect was greatly improved by the MCLs. (author abst.) |
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