Effect of Alfacalcidol on Bone and Calcium Metabolism in Elderly Women.
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Accession number;02A0191494
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| Title;Effect of Alfacalcidol on Bone and Calcium Metabolism in Elderly Women. |
| Author;
SAITO SHIN'ICHI
(Osakashidai Daigakuin'igakukenkyuka Taisha・naibumpitsubyotainaika)
NAKATSUKA KIYOSHI
(Osakashidai Daigakuin'igakukenkyuka Taisha・naibumpitsubyotainaika)
MIKI TAKAMI
(Osakashidai Ronennaika)
NAKA HIROSHI
(Osakashidai Ronennaika)
KITANI KAYOKO
(Osakashidai Daigakuin'igakukenkyuka Taisha・naibumpitsubyotainaika)
NISHIZAWA YOSHIKI
(Osakashidai Daigakuin'igakukenkyuka Taisha・naibumpitsubyotainaika)
MORII HIROTOSHI
(Aino Gakuin Tankidaigaku)
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Journal Title;Japanese Journal of Geriatrics
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Journal Code:Z0680A
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ISSN:0300-9173
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VOL.39;NO.1;PAGE.62-68(2002)
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| Figure&Table&Reference;FIG.4, TBL.2, REF.25 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Oral administration of active vitamin D3 can reduce the loss of bone mass and the incidence of fractures in patients with osteoporosis in Japan. We conducted a prospective study to confirm the effects of 1.ALPHA. (OH) D3 (Alfacalcidol, Alfarol Chugai Tokyo) on bone and calcium metabolism in elderly women with osteoporosis. Enrolled in the present study were 16 elderly osteoporosis women aged 72.6 .+-. 4.5 years to whom 1.MU.g of 1.ALPHA. (OH) D3 was administered daily. Fasting blood and urine were obtained at baseline. 1 week, 4 weeks, 12 weeks and 24 weeks after the treatment. Monitored parameters were vitamin D metabolites, intact-PTH, bone alkaline phosphatase (BAP), osteocalcin (OC), deoxypyridinoline (DPD) and pyridiuium crosslinked type I collagen telopeptides (CTx). Serum 1.ALPHA., 25 (OH) 2D and PTH levels were significantly increased (p<0.01) and decreased (p<0.05), respectively at 1 week after commencing administration. There was a significant decrease of DPD (p<0.05) at 12 weeks after commencing administration compared to the baseline levels. Serum levels of BAP and OC were found elevated at 1 week, and decreased at 12 weeks. In conclusion, the present study clinically confirmed that 1.ALPHA. (OH) D3 stimulates bone formation in vitro. Long-term administration of 1.ALPHA. (OH) D3 indirectly suppressed bone resorption through the suppression of parathyroid function in the elderly. (author abst.) |
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