Not Infrequent K-ras Mutations in Depressed-type Early Colorectal Carcinomas Larger than 10 mm.
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Accession number;02A0236721
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| Title;Not Infrequent K-ras Mutations in Depressed-type Early Colorectal Carcinomas Larger than 10 mm. |
| Author;
KAZAMA S
(Niigata Univ., Niigata)
AJIOKA Y
(Niigata Univ., Niigata)
WATANABE H
(Niigata Univ., Niigata)
WATANABE T
(Tokyo Univ., Tokyo)
NAGAWA H
(Tokyo Univ., Tokyo)
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Journal Title;Jpn J Cancer Res
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Journal Code:F0633A
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ISSN:0910-5050
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VOL.93;NO.2;PAGE.178-183(2002)
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| Figure&Table&Reference;FIG.2, TBL.3, REF.30 |
| Pub. Country;Japan |
| Language;English |
| Abstract;The aim of this study was to elucidate whether K-ras (codons 12 and 13) mutations occur in depressed-type early colorectal carcinomas (DECas) larger than 10 mm in size. Thirty-four cases of DECas including 27 larger than 10 mm were examined for K-ras mutations by means of microdissection, PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism), and direct sequencing. Although K-ras mutation was infrequent (1/7, 14%) in small (less than 10 mm) DECas, 16/27 (59%) and 17/27 (63%) of DECas larger than 10 mm revealed codon 12, or either codon 12 or 13 mutations, respectively. None of the evaluated pathological factors except size showed a correlation with K-ras mutation. These data indicate that although K-ras mutation could not be involved in the early stage of the progression of DECas, it might play a role at a later stage when the tumor size is over 10 mm. (author abst.) |
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