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Accession number;02A0208856
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| Title;Pathogenesis and Mechanisms of Tissue Destruction in Sjoegren's Syndrome. |
| Author;
HAYASHI YOSHIO
(Tokushimadai Shi Kokubyorigaku)
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Journal Title;Prog Med
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Journal Code:F0664B
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ISSN:0287-3648
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VOL.22;NO.1;PAGE.38-42(2002)
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| Figure&Table&Reference;FIG.3, REF.5 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We have investigated the pathogenesis of organ-specific autoimmune lesions in the salivary and lacrimal glands using an established animal model for Sjoegren's syndrome (SS) in NFS/sld mutant mice. We reported previuosly an organ-specific autoantigen in SS from the salivary glands in this murine model (Science 276: 604, 1997). A cleavage product of 120 kDa .ALPHA.-fodrin is an important autoantigen in the development of primary SS both in animal model and humans. We identified the immunodominant T cell epitope on .ALPHA.-fodrin autoantigen involved in antigenspecific immune responses in murine model of human SS. Autoreactive T cell clones that recognize synthetic N-terminal portion of .ALPHA.-fodrin were established, which produced Th1 cytokines, and showed significant cytotoxic activities against mouse salivary gland cells. Third complementary-determining regions (CDR3) of T cell receptor contained identical sequences in both autoreactive T cell clones and tissue-infiltrating T cells in vivo. Autoimmune lesions were induced by transfer of the autoreactive T cells into irradiated recipients, accompanying by CD4+V.BETA.6+ T cell infiltrates and "sicca syndrome". These results should help to elucidate the pathogenic mechanisms responsible for tissue destruction in primary SS and may have implications in the treatment of autoimmune disease. (author abst.) |
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