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Accession number;02A0208859
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| Title;Immunological Tests for Sjoegren's Syndrome (Autoantibodies). |
| Author;
TOJO TAKESHI
(Kokuritsubyointokyoiryose Naika)
AKIYA KUMIKO
(Kokuritsubyointokyoiryose Naika)
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Journal Title;Prog Med
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Journal Code:F0664B
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ISSN:0287-3648
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VOL.22;NO.1;PAGE.53-56(2002)
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| Figure&Table&Reference;REF.26 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The clinical significance of detecting anti-Ro/SS A and anti-La/SS B for the diagnosis of Sjoegren's syndrome (SS) were reviewed. These two antibodies have been widely accepted as useful and stable diagnostic tests for SS. The general high disease specificity has resulted in inclusion of these autoantibodies to the newly proposed classification criteria for SS in many countries. However the clinical significance of determining antibody profiles including anti-52kRo and anti-60kRo by ELISA using recombinant proteins as the antigen has not been fully understood. Most of anti-Ro positive patients with SS or SLE, have anti-52k and anti-60kRo antibodies. High titers of anti-52kRo are more common in SS than in SLE. Recombinant 52kRo-ELISA detects autoantibodies in SS that may go undetected by conventional serologic assays for anti-Ro/SS A. Antibodies against .ALPHA.-fodrin have been recently proposed as organ-specific autoantibodies in primary SS. The clinical usefulness of the antibody as a diagnostic test was reviewed. (author abst.) |
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