Short-Term Therapy of Statin Improves Arteries Stiffen by Its Anti-Oxidative and Anti-Inflammation in Patients with Hypercholesterolemia.
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Accession number;02A0208868
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| Title;Short-Term Therapy of Statin Improves Arteries Stiffen by Its Anti-Oxidative and Anti-Inflammation in Patients with Hypercholesterolemia. |
| Author;
MATSUO TAKASHI
(Kokuritsuyokohamabyoin Junkankika)
IWADE KAZUNORI
(Kokuritsuyokohamabyoin Junkankika)
HIRATA NAOMI
(Kokuritsuyokohamabyoin Junkankika)
YAMASHITA MICHIO
(Kokuritsuyokohamabyoin Junkankika)
IKEGAMI HARUHIKO
(Kokuritsuyokohamabyoin Junkankika)
TANAKA NAOHIDE
(Kokuritsuyokohamabyoin Junkankika)
AOSAKI MASAHIKO
(Kokuritsuyokohamabyoin Rinshokenkyubu)
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Journal Title;Prog Med
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Journal Code:F0664B
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ISSN:0287-3648
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VOL.22;NO.1;PAGE.129-133(2002)
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| Figure&Table&Reference;FIG.3, TBL.2, REF.14 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Backgrounds: The preventive effects of statins for coronary event are associated with not only cholesterol lowering effect but also pleiotropic direct effects to vascular wall, which are improving endothelial function, anti-oxidation and anti-inflammation. We investigated whether short-term statin therapy improves arteries stiffen and revealed its mechanism of action in patients with hypercholesterolemia. Method and Result: We assessed arteries stiffen in 10 patients (mean aged 62.9 .+-. 9.0) with hypercholesterolemia (total cholesterol.GEQ.220 mg/dL). The patients treated with cerivastatin 0.15 mg/day for 4 weeks. In baseline and after 4 weeks, we determined the arteries stiffen by brachial-ankle pulse wave velocity (baPWV), and ankle-brachial blood pressure index (ABI) using FOLM (Colin, Inc.). We also measured high sensitive C-reactive protein (hsCRP) and malondialdehide-low density lipoprotein (MDA-LDL) of blood sample as inflammation and oxidation markers. After statin therapy, both right and left baPWV were improved significantly from 1544.6 .+-. 157.1 to 1349.0 .+-. 223.9 (cm/sec) and 1592.1 .+-. 164.8 to 1424.8 .+-. 245.2 (cm/sec), respectively (p<0.05). ABI was unchanged between baseline and after 4 weeks. Furthermore, MDA-LDL decreased significantly (161.2 .+-. 42.4 U/L to 119.4 .+-. 33.5 U/L, p<0.05) and hsCRP tended to decrease. Total cholesterol and LDL-cholesterol decreased, and triglycerride and HDL-cholesterol were unchanged. Conclusion: These results suggest that the preventive effects of statins for coronary events are associated with its pleiotropic effects on vascular wall partially, and that statins are effective as not only cholesterol lowering agent but also anti-atherosclerotic agent. (author abst.) |
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