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Accession number;02A0368364
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| Title;Differential Roles between Epithelial and Stromal Cyclooxygenase-2 in Gastric Cancer. |
| Author;
TATSUGUCHI ATSUSHI
(Nippon Med. Sch.)
SAKAMOTO CHOITSU
(Nippon Med. Sch.)
TSUKUI TAKU
(Nippon Med. Sch.)
KOBAYASHI MASAFUMI
(Nippon Med. Sch.)
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Journal Title;Prog Med
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Journal Code:F0664B
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ISSN:0287-3648
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VOL.22;NO.3;PAGE.723-727(2002)
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| Figure&Table&Reference;FIG.3, REF.10 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;In vitro studies suggest that cyclooxygenase-2(COX-2) promotes angiogenesis via induction of angiogenic growth factors and inhibits apoptosis in cancer cell lines. The aims of this study are to evaluate the differential roles of stromal and epithelial COX-2 with respect to angiogenesis and apoptosis in gastric cancer tissues. A series of 107 gastric adenocarcinoma cases that had undergone gastrectomy was studied by means of immunohistochemical analysis. The reaction for COX-2 was positive in cancer cells and stromal cells in 46(43%) cases and 33 cases(31%), respectively. VEGF expression correlated with epithelial COX-2 expression. In addition, VEGF expression correlated with stromal COX-2 expression. Microvessel density was higher both in the cancer and stromal cells in COX-2-positive than in COX-2-negative cases. The apoptotic index was lower in the cancer cells in COX-2-positive than in COX-2-negative cases. However, there was no relationship between COX-2 expression in stromal cells and apoptotic index. In conclusion, there are differential roles between epithelial and stromal COX-2 with respect to angiogenesis and apoptosis in gastric cancer. (author abst.) |
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