Effect of Proglucagon-related Peptides on Interdigestive Upper Gastrointestinal Contractions.

Accession number;02A0368368
Title;Effect of Proglucagon-related Peptides on Interdigestive Upper Gastrointestinal Contractions.
Author; SHIBATA CHIKASHI (Tohokudai Daigakuin'igakukeikenkyuka Seitaichosetsugekagaku) NAITO HIROO (Tohokudai Daigakuin'igakukeikenkyuka Seitaichosetsugekagaku) JIN X-L (Tohokudai Daigakuin'igakukeikenkyuka Seitaichosetsugekagaku) MATSUNO SEIKI (Tohokudai Daigakuin'igakukeikenkyuka Seitaichosetsugekagaku) SASAKI IWAO (Tohokudai Daigakuin'igakukeikenkyuka Seitaichosetsugekagaku)
Journal Title;Prog Med
Journal Code:F0664B
ISSN:0287-3648
VOL.22;NO.3;PAGE.740-743(2002)
Figure&Table&Reference;FIG.3, REF.5
Pub. Country;Japan
Language;Japanese
Abstract;Our aim was to study the effect of proglucagon-related peptides, glucagon, glucagon-like peptide(GLP)-1, -2, and glicentin on gastroduodenal motility and their mechanisms of action. Methods: The effect of these 4 peptides on motilin-induced interdigestive contractions was studied in dogs with a vagally denervated gastric pouches equipped with 4 strain gauge force transducers on the pouch, gastric body, antrum, and duodenum. Whether or not nitric oxide synthase inhibitor, or phentolamine and propranolol reverses the inhibitory effect those peptides was also studied. Results: Glucagon inhibited contractions in the pouch and stomach, but had no effect on duodenal contractility. GLP-1 inhibited contractions at all sites. GLP-2 inhibited contractions in the pouch but did not affect motility in the neurally intact gastroduodenum. Glicentin had no effect on contractions at any site. Pretreatment with either a nitric oxide synthase inhibitor, or phentolamine and propranolol reversed the inhibitory effect of glucagon, GLP-1, and GLP-2 on contractions in the pouch, but did not alter the inhibitory effect of glucagon and GLP-1 on motility in the neurally intact stomach and duodenum. Conclusions: These results suggest that the effects of 4 peptides on gastroduodenal motility differ, and changes occur in the enteric neural modulation of motor activity after chronic surgical extrinsic denervation. (author abst.)
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