Fat Absorption and Hyperlipidemia in Streptozotocin Diabetic Rats.
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Accession number;02A0368370
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| Title;Fat Absorption and Hyperlipidemia in Streptozotocin Diabetic Rats. |
| Author;
IYAMA MINEKAZU
(Osaka Medical. Coll., JPN)
UMEGAKI EIJI
(Osaka Medical. Coll., JPN)
SHIMAMOTO CHIKAO
(Osaka Medical. Coll., JPN)
SHIOZAKI MICHIAKI
(Osaka Medical. Coll., JPN)
NANRI MASASHI
(Osaka Medical. Coll., JPN)
EIRAKU CHIKAKO
(Osaka Medical. Coll., JPN)
HIRATA ICHIRO
(Osaka Medical. Coll., JPN)
KATSU KEN'ICHI
(Osaka Medical. Coll., JPN)
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Journal Title;Prog Med
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Journal Code:F0664B
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ISSN:0287-3648
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VOL.22;NO.3;PAGE.749-752(2002)
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| Figure&Table&Reference;FIG.3, REF.8 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The morphological and functional changes in fat absorption of the small intestinal villi were examined in rats to elucidate the etiology of hyperlipidemia under insulin-dependent diabetes mellitus. In streptozotocin(STZ) diabetic and control male Wistar rats, the height of the small intestinal villus was measured under microscope with a videomicrometer. Fat absorption was examined by 13C-trioctanoin breath test, and evaluated by measurement of the peak excretion rate 13CO2. A decrease in the serum insulin value and increases in blood sugar, HbA1c, total cholesterol, and triglyceride were noted in the STZ group. The height of the small intestinal villi and the peak excretion rate of 13CO2 were significantly greater in the STZ group than in the control group. Histological hyperplasia of the small intestinal villi and increase fat absorption were noted in the STZ group. An increase in the absorbing area due to small intestine villi hyperplasia and thus an increase in fat absorption, might be one cause of hyperlipidemia in fat absorption in rats with insulin-dependent diabetes mellitus. (author abst.) |
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