Autonomic Innervation of Esophageal Cardial Gland-Relation to Effector Sites of Lansoprazole.
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Accession number;02A0368371
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| Title;Autonomic Innervation of Esophageal Cardial Gland-Relation to Effector Sites of Lansoprazole. |
| Author;
NAKAMURA MASAHIKO
(Kitasato Inst. Res. Division, JPN)
TSUCHIMOTO KANJI
(Kitasato Inst. Hosp., Kitasato Inst.)
MATSUI HIDENORI
(Kitasato Inst. Res. Division, JPN)
AKIBA YASUTADA
(Keio Univ.)
ODA MASAYA
(Kokusaiiryofukushidai Rinshokense)
ISHII HIROMASA
(Keio Univ.)
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Journal Title;Prog Med
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Journal Code:F0664B
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ISSN:0287-3648
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VOL.22;NO.3;PAGE.753-756(2002)
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| Figure&Table&Reference;FIG.5, REF.4 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Recently the increased incidence of reflux esophagitis, Barrett esophagus and cardial cancer has attracted attention especially after the Helicobacter pylori eradication. In this connection, lansoprazole, one of the proton pump inhibitors, has been reported to increase the bicarbonate secretion in the duodenum, which suggests that this agent could stimulate the bicarbonate secretion from the esophagus. Thus, the present study was undertaken to clarify the distribution of mesenchymal cells surrounding the esophageal mucous gland and binding sites of 3H-lansoprazole in the bullfrog esophagus. The distribution of the H+,K+-ATPase and calcitonin gene-related peptide was investigated by indirect immunohistochemical method using monoclonal antibodies and observed by confocal laser microscopy. The localization of 3H-lansoprazole binding sites was clarified by two kinds of autoradiographic procedures including in vitro autoradiography and autoradiography of soluble compounds. As a result, the bullfrog esophageal mucous gland was richly surrounded by the CGRP-immunoreactive nerve fibers. The binding sites of 3H-lansoprazole was mostly accumulated on the mesenchymal cells just adjacent to the esophageal mucous glands, which coincided with the localization of autonomic nerve fibers. In conclusion, lansoprazole was suggested to have some effect on the autonomic nerves in the esophageal mucous glands. (author abst.) |
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