EGF Receptor Transactivation by IL-8.
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Accession number;02A0368372
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| Title;EGF Receptor Transactivation by IL-8. |
| Author;
JO TAKASHI
(Nagoya City Univ., Med. Sch.)
WATANABE KATSUSHI
(Nagoya City Univ., Med. Sch.)
ITO YUSUKE
(Nagoya City Univ., Med. Sch.)
TANIDA SATOSHI
(Nagoya City Univ., Med. Sch.)
SENOO KYOJI
(Nagoya City Univ., Med. Sch.)
YOKOYAMA YOSHIFUMI
(Nagoya City Univ., Med. Sch.)
HIGASHIYAMA SHIGEKI
(Osakadai I Hokengakka Bunshiseikagaku)
ITO MAKOTO
(Nagoya City Univ., Med. Sch.)
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Journal Title;Prog Med
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Journal Code:F0664B
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ISSN:0287-3648
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VOL.22;NO.3;PAGE.759-761(2002)
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| Figure&Table&Reference;FIG.3, REF.4 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;This study was conducted to determine if IL-8 activates EGF receptor on gastrointestinal epithelial cells via membrane anchored metalloproteinase, ADAM, which releases EGF ligands from membrane anchored precursors. IL-8 phosphorylated EGF receptor on Kato III cells within 15min. This phosphorylation was significantly blocked by pretreatment with ADAM inhibitor 7795. These data indicate that IL-8 may stimulate a growth of gastrointestinal epithelium by transactivating EGF receptor in an ADAM dependent manner. This system including ADAMs and EGF receptor ligands may play a key role in various pathological condition of gastrointestinal disorders. (author abst.) |
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