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Accession number;02A0368376
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| Title;Effect of Mosapride Citrate on Esophageal Motility in Healthy Subjects and Patients with Gastroesophageal Reflux Disease. |
| Author;
MITSUFUJI SHOJI
(Kyoto Prefect. Univ. of Med. Fac. of Med.)
NAKAO HIROKO
(Kyoto Prefect. Univ. of Med. Fac. of Med.)
TANIGUCHI JUNKO
(Kyoto Prefect. Univ. of Med. Fac. of Med.)
NODA AYAKO
(Kyoto Prefect. Univ. of Med. Fac. of Med.)
NODA MASAO
(Kyoto Prefect. Univ. of Med. Fac. of Med.)
KONISHI HIDEYUKI
(Kyoto Prefect. Univ. of Med. Fac. of Med.)
WAKABAYASHI NAOKI
(Kyoto Prefect. Univ. of Med. Fac. of Med.)
KASHIMA KEI
(Kyoto Prefect. Univ. of Med. Fac. of Med.)
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Journal Title;Prog Med
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Journal Code:F0664B
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ISSN:0287-3648
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VOL.22;NO.3;PAGE.801-805(2002)
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| Figure&Table&Reference;FIG.6, REF.14 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We evaluated the effect of mosapride citrate(Gasmotin) which is a selective 5-HT4 receptor agonist on esophageal motility. Esophageal manometry was performed before and after administration of 10mg dose of mosapride citrate in seven healthy volunteers and 13 patients with gastroesophageal reflux disease(GERD). The values of lower esophageal sphincter(LES) pressure, pressure wave amplitude and propagation velocity of pressure wave after administration of mosapride citrate were significantly higher than basal values in both healthy volunteers and GERD patients. These results indicate that mosapride citrate enhances the esophageal motility and therefore has the potential efficacy of treatment of GERD. (author abst.) |
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