Science Links Japan | Protective Effect of Famotidine on Acidified Aspirin-induced Gastric Mucosal Injury in Rats.

Protective Effect of Famotidine on Acidified Aspirin-induced Gastric Mucosal Injury in Rats.

Accession number;02A0368380

Title;Protective Effect of Famotidine on Acidified Aspirin-induced Gastric Mucosal Injury in Rats.

Author; YOSHIDA NORIMASA (Kyoto Prefect. Univ. of Med. Fac. of Med.) YAGI NOBUAKI (Kyoto Prefect. Univ. of Med. Fac. of Med.) MATSUYAMA KIICHI (Kyoto Prefect. Univ. of Med. Fac. of Med.) TAKAGI TOMOHISA (Kyoto Prefect. Univ. of Med. Fac. of Med.) ICHIKAWA HIROSHI (Kyoto Prefect. Univ. of Med. Fac. of Med.) NAITO YUJI (Kyoto Prefect. Univ. of Med. Fac. of Med.) YOSHIKAWA TOSHIKAZU (Kyoto Prefect. Univ. of Med. Fac. of Med.)

Journal Title;Prog Med

Journal Code:F0664B

ISSN:0287-3648

VOL.22;NO.3;PAGE.826-830(2002)

Figure&Table&Reference;FIG.3, REF.16

Pub. Country;Japan

Language;Japanese

Abstract;We examined the effect of famotidine in aspirin-induced gastric mucosal injury in rats. Acidified aspirin-induced gastric damage, the increase in myeloperoxidase activity and the levels of tumor necrosis factor alpha were significantry inhibited by the administration of famotidine. These results suggest that famotidine protects against neutrophil-mediated inflammatory reaction in aspirin-induced gastric mucosal injury in rats. (author abst.)

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