Science Links Japan | Allogeneic Bone Marrow Transplantation for a Carrier of Vancomycin-resistant Enterococcus Faecim.

Allogeneic Bone Marrow Transplantation for a Carrier of Vancomycin-resistant Enterococcus Faecim.

Accession number;02A0168952

Title;Allogeneic Bone Marrow Transplantation for a Carrier of Vancomycin-resistant Enterococcus Faecim.

Author; MANKI AKIRA (Okayamadai Daigakuin'ishigakusogokenkyuka Shoniikagaku) NISHIUCHI RITSUO (Okayamadai Daigakuin'ishigakusogokenkyuka Shoniikagaku) EGUCHI NAOHIRO (Okayamadai Daigakuin'ishigakusogokenkyuka Shoniikagaku) INOUE TAKUYA (Okayamadai Daigakuin'ishigakusogokenkyuka Shoniikagaku) URAKAMI TOMOKO (Okayamadai Daigakuin'ishigakusogokenkyuka Shoniikagaku) MIYAMURA TAKAKO (Okayamadai Daigakuin'ishigakusogokenkyuka Shoniikagaku) KADO YUJI (Okayamadai Daigakuin'ishigakusogokenkyuka Shoniikagaku) ODA MEGUMI (Okayamadai Daigakuin'ishigakusogokenkyuka Shoniikagaku) SEINO YOSHIKI (Okayamadai Daigakuin'ishigakusogokenkyuka Shoniikagaku)

Journal Title;Journal of the Japan Pediatric Society

Journal Code:F0896A

ISSN:0001-6543

VOL.106;NO.1;PAGE.67-70(2002)

Figure&Table&Reference;FIG.2, TBL.2, REF.9

Pub. Country;Japan

Language;Japanese

Abstract;This article examines a case of allogeneic bone marrow transplantation (BMT) in an acute myeloblastic leukemia patient colonized with class A vancomycin (VCM)-resistant enterococcus faecium (VRE). We did not try to eradicate the VRE during conventional chemotherapy even though the stool and urine cultures were repeatedly positive for VRE. At the time of BMT, we used oral norfloxacin (NFLX) that the VRE was still sensitive to. Then the VRE became negative for all specimens in the second week after BMT. VCM-sensitive and quinolone-low-sensitive enterococcus faecium were isolated from stools on the second day after BMT and replaced the VRE for the following months. The patient did not have VRE bacteremia during pre- and post-BMT. NFLX would be effective for eliminating VRE in the patient. For prevention of additional acquisition of NFLX-resistance, however, NFLX should he administrated in a short-period including both the first and second week after BMT when there is a high risk of VRE bacteremia. (author abst.)

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