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Accession number;02A0168955
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| Title;Continuous Hemodialysis Filtration (CHDF) Therapy for Acute Necrotising Encephalopathy Associated with Serious Liver Dysfunction and Renal Failure. |
| Author;
IKEDA HIROKAZU
(Kanagawakenkodomoiryose Kansenmen'ekika)
AKAGI KUNIHIKO
(Kanagawakenkodomoiryose Kansenmen'ekika)
TAKAHASHI EIHIKO
(Kanagawakenkodomoiryose Kansenmen'ekika)
OKUYAMA NOBUHIKO
(Kanagawakenkodomoiryose Kansenmen'ekika)
SHIKAMA YOSHIAKI
(Kanagawakenkodomoiryose Kansenmen'ekika)
TANAKA YUKICHI
(Kanagawa Child. Med. Center)
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Journal Title;Journal of the Japan Pediatric Society
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Journal Code:F0896A
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ISSN:0001-6543
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VOL.106;NO.1;PAGE.81-84(2002)
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| Figure&Table&Reference;FIG.2, TBL.2, REF.5 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;A nine-year-old boy with influenza B related acute necrotizing encephalopathy associated with serious liver dysfunction, coagulopathy and acute renal failure was given continuous hemodialysis filtration (CHDF) using PMMA membrane. The imaging analysis revealed bilateral symmetrical lesions in thalamic and cerebellar lesion, and this finding was well compatible with acute necrotizing encephalopathy described by Mizuguchi et al. The liver biopsy showed hepatic centrilobular necrosis. The results of anti-ICAM-1 antibody staining were similar to those of ischemia-reperfusion disorder. Renal biopsy showed acute tubular necrosis. After the execution of CHDF, liver dysfunction and coagulopathy rapidly improved, and unconsciousness also improved. Renal function recovered after four sessions of dialysis. CHDF has been reported to be highly efficient in removing the solutes of small to medium molecules and being helpful to normalize the acid-base balance in local tissues associated with peripheral circulation failure or hypoxia. These results suggested that CHDF may be an effective method in the treatment of influenza encephalitis/encephalopathy and further studies will be needed. (author abst.) |
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