A Case of Rheumatoid Arthritis Complicated with a Pneumonitis During Concomitant Treatment with Methotrexate and Bucillamine.
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Accession number;02A0315493
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| Title;A Case of Rheumatoid Arthritis Complicated with a Pneumonitis During Concomitant Treatment with Methotrexate and Bucillamine. |
| Author;
MIWA YUSUKE
(Showadai Riumachikogenbyonaika)
KAGA SHUJI
(Showadai Riumachikogenbyonaika)
HANAOKA RYOSUKE
(Showadai Riumachikogenbyonaika)
SHIOZAWA FUMITAKA
(Showadai Riumachikogenbyonaika)
HANYUDA MICHIO
(Showadai Riumachikogenbyonaika)
KASAMA TSUYOSHI
(Showadai Riumachikogenbyonaika)
NEGISHI MASAO
(Showadai Riumachikogenbyonaika)
IDE HIROTSUGU
(Showadai Riumachikogenbyonaika)
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Journal Title;Official Journal of Japan College of Rheumatology
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Journal Code:Z0690A
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ISSN:0300-9157
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VOL.42;NO.1;PAGE.70-75(2002)
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| Figure&Table&Reference;FIG.5, REF.16 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;A 70-year-old female was diagnosed as having rheumatoid arthritis (RA) in 1971, which was then treated with steroid and nonsteroidal anti-inflammatory drugs. In 1999, after total replacement of her knee joint, 4mg of methotrexate (MTX) per week was administered. Two months after the MTX administration, 200mg of bucillamine per day was administered. On May 10, 2001, the patient was rushed to the hospital due to fever and difficulty in breathing. Chest X-ray and computed tomography (CT) revealed shadows of ground-glass-like opacity occurring sporadically in many places in the upper lung field bilaterally and interstitial shadows mainly on the lateral side of the lower lung field bilaterally. Instead of MTX and bucillamine, which were withheld, an MTX antagonist was administered and oxygen-supported therapy was performed; consequently, the patient recovered without the need to increase the amount of steroid. The percentage of lymphocytes in the bronchoalveolar lavage fluid increased to 72%, and the CD 4/CD 8 ratio to 3.13. The level of serum KL-6 increased while that of serum SP-D returned to the normal level at different time. Following MTX and bucillamine administration, shadows of ground-glass-like opacity occurred sporadically in many places in the upper lung field bilaterally, which is not usually observed. It is suggested that such an unusual pulmonary disorder occurred due to concomitant use of drugs or other factors. (author abst.) |
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