Prognostic Significance of Matrix Metalloproteinase-7 (MMP-7) Expression at the Invasive Front in Gastric Carcinoma.
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Accession number;02A0357266
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| Title;Prognostic Significance of Matrix Metalloproteinase-7 (MMP-7) Expression at the Invasive Front in Gastric Carcinoma. |
| Author;
LIU X P
(Yamaguchi Univ. School Of Medicine, Yamaguchi)
KAWAUCHI S
(Yamaguchi Univ. School Of Medicine, Yamaguchi)
OGA A
(Yamaguchi Univ. School Of Medicine, Yamaguchi)
TSUSHIMI K
(Tsushimi Hospital, Yamaguchi)
TSUSHIMI M
(Tsushimi Hospital, Yamaguchi)
FURUYA T
(Yamaguchi Univ. School Of Medicine, Yamaguchi)
SASAKI K
(Yamaguchi Univ. School Of Medicine, Yamaguchi)
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Journal Title;Jpn J Cancer Res
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Journal Code:F0633A
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ISSN:0910-5050
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VOL.93;NO.3;PAGE.291-295(2002)
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| Figure&Table&Reference;FIG.3, TBL.2, REF.22 |
| Pub. Country;Japan |
| Language;English |
| Abstract;To evaluate the clinicopathological significance of matrix metalloproteinase-7 (MMP-7) expression in gastric carcinoma, we investigated immunohistochemically MMP-7 expression in 214 gastric carcinomas, and examined its relations with the clinicopathologic parameters including patient prognosis. MMP-7 expressed predominantly in cancer cells, and MMP-7-positive tumor cells were preferentially found in deeply invading nests, especially at the invasive front. The mean MMP-7 labeling index (LI) at the invasive front was significantly higher in tumors invading or penetrating the muscularis propria and in stages II-IV than within the submucosal layer and in stage I, respectively (P<0.001). Statistical analysis revealed that MMP-7 LI at the invasive front was related to lymph node metastasis, vascular invasion, and lymphatic permeation, when all 214 cases were examined as one group (P<0.05 for all), and the cases with high MMP-7 expression at the invasive front showed significantly more unfavorable prognosis as compared with that of low MMP-7 expression tumors (P<0.01). Multivariate analysis revealed that TNM stage and MMP-7 expression status at the invasive front were independent prognostic factors (P=0.0017, relative risk (RR)=3.12; P=0.0019, RR=2.67, respectively). Our findings indicated that expression of MMP-7 at the invasive front is closely associated with local invasiveness, and might be a reliable prognostic marker for patients with gastric carcinoma. (author abst.) |
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