The effects of Saiko-keishi-to and Juzen-taiho-to on Th1-Th2 balance in different age mice.
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Accession number;02A0339248
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| Title;The effects of Saiko-keishi-to and Juzen-taiho-to on Th1-Th2 balance in different age mice. |
| Author;
JIN G-B
(Oriental Medicine Res. Center Of The Kitasato Inst., Tokyo)
WATANABE K
(Oriental Medicine Res. Center Of The Kitasato Inst., Tokyo)
NAKADA T
(Oriental Medicine Res. Center Of The Kitasato Inst., Tokyo)
SANTA K
(Oriental Medicine Res. Center Of The Kitasato Inst., Tokyo)
KATO H
(Oriental Medicine Res. Center Of The Kitasato Inst., Tokyo)
MATSUMOTO T
(Oriental Medicine Res. Center Of The Kitasato Inst., Tokyo)
TORIIZUKA K
(Oriental Medicine Res. Center Of The Kitasato Inst., Tokyo)
HANAWA T
(Oriental Medicine Res. Center Of The Kitasato Inst., Tokyo)
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Journal Title;Journal of Traditional Medicines
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Journal Code:Y0941A
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ISSN:1340-6302
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VOL.19;NO.1;PAGE.7-14(2002)
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| Figure&Table&Reference;FIG.3, TBL.1, REF.52 |
| Pub. Country;Japan |
| Language;English |
| Abstract;It has been reported that traditional Japanese herbal medicines (Kampo medicines) are effective to treat patients with atopic constitution. These allergic responses are characterized by the Th2-mediated helper T lymphocytes. However, it seems that effects of Kampo medicines are different according to the patient's age. In this study, we investigated the effects of Kampo medicines, Saiko-keishi-to (SKT; ) and Juzen-taiho-to (JTT; ), on Th1-Th2 balance in splenic T cells of BALB/c neonate mice, and at 8 and 25 weeks old. The alterations of splenic T lymphocyte subpopulations were observed both in neonate and 8 week old mice, where the ratios of CD4/CD8 decreased significantly both in SKT treated neonate and SKT treated 8 week old mice compared to corresponding control groups. The ratio of CD3/CD19 decreased significantly only in SKT treated neonate mice. However, in JTT treated groups, no significant difference was observed at any age. Splenocytes were cultured with anti-mouse CD3 mAb, and the resulting supernatant was subjected to the determination of cytokine production using ELISA. Neither SKT nor the JTT treated group showed significant change of IFN-.GAMMA. production. However, IL-4 productions in SKT and JTT treated groups significantly reduced both in neonate and 8 week old mice compared to corresponding control mice, and IL-12 production in SKT treated group decreased in neonate mice. In contrast, no change of IL-4 production was observed in splenic lymphocyte subpopulations and cytokine productions in 25 week old mice. These results indicated that oral administration of Kampo medicines (SKT and JTT) on Th1-Th2 balance were different according to aging. (author abst.) |
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