Immunopharmacological properties of Oren-gedoku-to (a Kampo medicine, Huang-Lian-Jie-Du-Tang) on contact hypersensitivity reaction in mice.
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Accession number;02A0339250
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| Title;Immunopharmacological properties of Oren-gedoku-to (a Kampo medicine, Huang-Lian-Jie-Du-Tang) on contact hypersensitivity reaction in mice. |
| Author;
TATSUMI T
(Toyama Medical And Pharmaceutical Univ., Toyama, Jpn)
TERASAWA M
(Toyama Medical And Pharmaceutical Univ., Toyama, Jpn)
TEGA E
(Toyama Medical And Pharmaceutical Univ., Toyama, Jpn)
HAYAKAWA Y
(Toyama Medical And Pharmaceutical Univ., Toyama, Jpn)
TERASAWA K
(Toyama Medical And Pharmaceutical Univ., Toyama, Jpn)
SAIKI I
(Toyama Medical And Pharmaceutical Univ., Toyama, Jpn)
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Journal Title;Journal of Traditional Medicines
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Journal Code:Y0941A
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ISSN:1340-6302
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VOL.19;NO.1;PAGE.21-27(2002)
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| Figure&Table&Reference;FIG.5, REF.24 |
| Pub. Country;Japan |
| Language;English |
| Abstract;We investigated the effects of Oren-gedoku-to (Huang-Lian-Jie-Du-Tang), a Kampo medicine, on DNFB-induced contact hypersensitivity(CHS) response in mice in order to further clarify the immunopharmacological properties of this formulation. 1) Administration of Oren-gedoku-to decreased the magnitude of ear swelling in the CHS response and shortened the affected period. The inhibitory effect on ear swelling was observed even when Oren-gedoku-to was given orally with different timing schedules. 2) The expressions of mRNAs for CD8, IFN-.GAMMA. and TNF-.ALPHA. in the ear of Oren-gedoku-to-treated mice were markedly decreased 24h after the challenge. 3) The number of skin-draining regional lymph node cells (LNCs), CD4+ T cells and CD8+ T cells was decreased without affecting the ratio of CD8+/CD4+ T cells. 4) Oren-gedoku-to resulted in a marked impairment of the hapten-specific development of LNCs. These results suggest that the suppressive effect of Oren-gedoku-to on ear swelling was partly caused by the suppression of lymphocyte proliferation. (author abst.) |
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