Exendin-4, a GLP-1 Receptor Agonist, Stimulates Rat Pituitary-Adrenocortical Axis.
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Accession number;02A0375384
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| Title;Exendin-4, a GLP-1 Receptor Agonist, Stimulates Rat Pituitary-Adrenocortical Axis. |
| Author;
MALENDOWICZ L K
(Poznan School Of Medicine, Poznan, Pol)
NOWAK K W
(August Cieszkowski Univ. Agriculture, Poznan, Pol)
NUSSDORFER G G
(Univ. Padua, Padua, Ita)
ZYTERSKA A
(August Cieszkowski Univ. Agriculture, Poznan, Pol)
REBUFFAT P
(Univ. Padua, Padua, Ita)
NOWAK M
(Poznan School Of Medicine, Poznan, Pol)
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Journal Title;Biomed Res
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Journal Code:Z0236B
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ISSN:0388-6107
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VOL.22;NO.6;PAGE.273-276(2001)
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| Figure&Table&Reference;FIG.2, REF.16 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Preproglucagon-derived peptides, among which glucagon and glucagon-like peptide-1(GLP-1), are known to modulate the activity of the hypothalamo-pituitary-adrenal(HPA) axis. Many effects of GPL-1, however, are prevented by its very short half-life. Hence we investigated in vivo and in vitro the effects on the rat HPA axis of the GLP-1-receptor agonist exendin-4(EX4), which possesses a longer biological half-life than GLP-1. The bolus systemic administration of EX4 (12nmol/kg) evoked significant rises in ACTH, aldosterone and corticosterone concentrations. EX4 (10-7M) induced a weak but significant increase in corticosterone secretion from dispersed rat adrenocortical cells, and the effect was abrogated by the GLP-1-receptor antagonist exendin (9-39). Collectively, our findings indicate that EX4, acting via GLP-1 receptors, stimulates HPA axis in rats, acting on both its central (hypothalamo-pituitary) and peripheral (adrenocortical) branch. (author abst.) |
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