Science Links Japan | Differences in the influences of ovariectomy and orchiectomy on the remodeling of mandibular condyle and femora in mice.

Differences in the influences of ovariectomy and orchiectomy on the remodeling of mandibular condyle and femora in mice.

Accession number;02A0375387

Title;Differences in the influences of ovariectomy and orchiectomy on the remodeling of mandibular condyle and femora in mice.

Author; FUJITA T (Hiroshima Univ. Fac. Dentistry, Hiroshima, Jpn) KAWATA T (Hiroshima Univ. Fac. Dentistry, Hiroshima, Jpn) OHTANI J (Hiroshima Univ. Fac. Dentistry, Hiroshima, Jpn) KAKU M (Hiroshima Univ. Fac. Dentistry, Hiroshima, Jpn) TOKIMASA C (Hiroshima Univ. Fac. Dentistry, Hiroshima, Jpn) KOHNO S (Hiroshima Univ. Fac. Dentistry, Hiroshima, Jpn) TSUTSUI K (Hiroshima Univ. Fac. Dentistry, Hiroshima, Jpn) TENJO K (Hiroshima Univ. Fac. Dentistry, Hiroshima, Jpn) TANNE K (Hiroshima Univ. Fac. Dentistry, Hiroshima, Jpn)

Journal Title;Biomed Res

Journal Code:Z0236B

ISSN:0388-6107

VOL.22;NO.6;PAGE.291-294(2001)

Figure&Table&Reference;FIG.8, REF.14

Pub. Country;Japan

Language;English

Abstract;Ovariectomy(OVX) and orchiectomy(ORX) are well known to increase bone turnover, however, the osteogenic effects are not fully understood. In this study, influences of sex hormone secretion cessation was examined for both sexes and different bones in terms of the change in the number of osteoblasts regarded as an index of bone formation. Male and female mice underwent ORX and OVX at 8 weeks old, respectively. In each of the experimental and control groups, mice were sacrificed 4 weeks after the surgery for OVX and ORX. The experimental mice exhibited an increase in the number of the osteoblasts in the condylar head, significantly different from the controls. Furthermore, in the experiment groups, the number of osteoblasts exhibited a more remarkable increase in the condyle than in the femora. This finding suggests that bone formation is accelerated by the reduction of sex hormone levels and the decrease in the trabecular bone volume is different between bones accordin to the degree of the enhanced bone formation or osteogenic activity. (author abst.)

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