Exendin-4, a GLP-1 receptor agonist, stimulates entero-insular axis in the rat, through a mechanism involving adrenal medulla.
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Accession number;02A0375388
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| Title;Exendin-4, a GLP-1 receptor agonist, stimulates entero-insular axis in the rat, through a mechanism involving adrenal medulla. |
| Author;
MALENDOWICZ L K
(School Of Medicine, Pol)
NOWAK K W
(August Cieszkowski Univ. Agriculture, Poznan, Pol)
ZYTERSKA A
(August Cieszkowski Univ. Agriculture, Poznan, Pol)
NUSSDORFER G G
(Univ. Padua, Padua, Ita)
MACCHI C
(Univ. Padua, Padua, Ita)
NOWAK M
(School Of Medicine, Pol)
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Journal Title;Biomed Res
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Journal Code:Z0236B
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ISSN:0388-6107
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VOL.22;NO.6;PAGE.295-297(2001)
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| Figure&Table&Reference;FIG.1, REF.11 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Glucagon-like peptide-1(GLP-1) is known to lower blood glucose level, the effect depending on the stimulation of insulin and the inhibition of glucagon secretion. Due to the rapid inactivation of GLP-1 by dipeptidyl peptidase-IV(DPP-IV), its biological action is very short. Hence, we investigated the effect on rat entero-insular axis of exendin-4, a DPP-IX-resistant agonist of GPL-1 receptors. As expected the bolus administration of exendin-4 (12nmol/kg) increased the plasma concentration of insulin and decreased the blood levels of both glucagon and leptin in normal rats; however, GLP-1 raised glycemia. Exendin-4 did not evoke any effect in rats bearing enucleated-regenerated adrenals deprived of medullary tissue, thereby suggesting that its stimulating effect of entero-insular axis occurs via an indirect mechanism probably involving medullary catecholamines. Catecholamines are potent stimulator of hepatic glycogenolysis, and this may tentatively explain the hyperglycemizing effect of exendin-4. (author abst.) |
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