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Accession number;02A0472872
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| Title;The induction of ADRG#34 after chromic antidepressant treatment and repeated electroconvlusive treatment in rat brain. |
| Author;
YAMADA MITSUHIKO
(Showadai Karasuyamabyoin Seishin'igaku)
KAMIJIMA KUNITOSHI
(Showadai I Seishin'igaku)
HIGUCHI TERUHIKO
(Kokuritsu Seishin Shinkei Senta Konodai Byoin)
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Journal Title;Annual Report of the Pharmacopsychiatry Research Foundation
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Journal Code:Y0939A
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ISSN:0286-7591
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VOL.;NO.34;PAGE.45-51(2002)
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| Figure&Table&Reference;FIG.6, REF.6 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Previously, we have identified 200 cDNA fragments as antidepressant related genes/ESTs (ADRG#1-200). In this study, using these cDNAs, we developed our original cDNA microarray for rapid secondary screening of candidate genes as the novel therapeutic targets. With this microarray, we found that the expression of a novel gene, ADRG#34, was significantly increased in rat frontal cortex after chronic antidepressant treatment and repeated electroconvulsive treatment(ECT), another therapeutic treatment of depression. RT-PCR analysis also demonstrated the induction of ADRG#34 at mRNA levels in rat frontal cortex after these treatment. On the other hand, single administration had no effect on ADRG#34 expression. We then determined the full length of ADRG#34 encoded 685 amino acid residues containing a RING-H2 finger motif at the carboxy-terminal. Our data suggest that ADRG#34 may be one of the common functional molecules induced after chronic antidepressant treatment and ECT. Our results may contribute to a novel model for the therapeutic mechanism of depression and new molecular targets for the development of therapeutic agents. (author abst.) |
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