|
Accession number;02A0472873
|
| Title;The investigation of the bHLH transcription factor changed by mood stabilizer. |
| Author;
OSADA KEN'ICHI
(Seimariannaidai Shinkeiseishinka)
MISONO ATSUSHI
(Seimariannaidai Shinkeiseishinka)
HASEGAWA HIROSHI
(Seimariannaidai Shinkeiseishinka)
HISHINUMA TAKUJI
(Seimariannaidai Shinkeiseishinka)
TANAKA DAISUKE
(Seimariannaidai Shinkeiseishinka)
FUJII SAWAKO
(Seimariannaidai Shinkeiseishinka)
NAGASHIMA HIDEAKI
(Seimariannaidai Shinkeiseishinka)
ASAKURA MIKIO
(Seimariannaidai Yokohamashiseibubyoin Shinkeiseishinka)
|
Journal Title;Annual Report of the Pharmacopsychiatry Research Foundation
|
Journal Code:Y0939A
|
ISSN:0286-7591
|
|
VOL.;NO.34;PAGE.52-57(2002)
|
| Figure&Table&Reference;FIG.4, REF.7 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Lithium is a mood stabilizer used in treatment of bipolar disorders. We reported that GAP-43 protein was induced after 4-5 weeks lithium treatment. We examined the GAP-43 RNA expression after longterm treatment with lithium in the rat brain. GAP-43 RNA also increased in rat cerebral cortex after 4-5 weeks treatment with lithium. The E-box binding protein to the GAP-43 promoter was decreased after 4-5 weeks lithium treatment. Since the decrease of E-box binding protein preceded increased GAP-43 mRNA expression, it is suggested that E-box binding protein to the GAP-43 promoter could negatively regulate GAP-43 gene expression. It was thus suggested that the lithium increase in GAP-43 mRNA and GAP-43 protein level by E-box binding protein. GAP-43 is known to play an important role in the releasing process for several neurotransmitters(Ach,5-HT and DA). It was considered that the long-term lithium treatment regulated GAP-43 and release of neurotransmitters by E-box binding protein. (author abst.) |
|
|
|
Related Articles;
|
