|
Accession number;02A0472874
|
| Title;Candidate gene approach at the susceptible region of chromosome 21q22.3 for bipolar disorder. A novel putative Ca2+ channel protein TRPC7. |
| Author;
SHIOE KUNIHIKO
(Yamanashiidai Seishinshinkeiigaku)
HIRANO MASAMI
(Yamanashiidai Hokenkanrise)
NAKAZAWA MIE
(Yamanashiidai Seishinshinkeiigaku)
SHINOHARA MANABU
(Yamanashiidai Seishinshinkeiigaku)
KUDO JUN
(Keiodai I Bunshiseibutsugaku)
MINOSHIMA SHINSEI
(Keiodai I Bunshiseibutsugaku)
SHIMIZU NOBUYOSHI
(Keiodai I Bunshiseibutsugaku)
KAMBA SHIGENOBU
(Yamanashiidai Seishinshinkeiigaku)
|
Journal Title;Annual Report of the Pharmacopsychiatry Research Foundation
|
Journal Code:Y0939A
|
ISSN:0286-7591
|
|
VOL.;NO.34;PAGE.58-64(2002)
|
| Figure&Table&Reference;FIG.2, TBL.4, REF.14 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We have isolated cDNA clones for a novel human protein TRPC7(Transient Receptor Potential related Channels), consists of 1,503 amino acid residues from fetal brain and caudate nucleus cDNA libraries. Genomic sequence analysis shows that the TRPC7 gene is composed of thirty-two exons and spans approximately 90kb, and has seven putative transmembrane domains that probably constitute a Ca2+ channel. The TRPC7 gene is highly expressed as a 6.5-kb transcript in brain by means of Northern blot analysis. The TRPC7 gene was mapped between D21S400 and D21S171 on human chromosome 21q22.3, which is a candidate region for bipolar mood disorder. We have identified several single nucleotide polymorphisms, one of all exists in coding region, accompanied with substitution of amino acid("missense"). Then, we performed an association study of bipolar patients related to this candidate gene. The detailed results of the association study will be presented in the near future. (author abst.) |
|
|
|
Related Articles;
|
