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Accession number;02A0472876
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| Title;The Longitudinal Study of Neuroendocrine and Brain Metabolic Dysfunction in Depression. DEX/CRH and [18F] FDG-PET. |
| Author;
AIHARA MASAKO
(Gunmadai I Shinkeiseishin'igaku)
IDA ITSURO
(Gunmadai I Shinkeiseishin'igaku)
MAJIMA TAKEHIKO
(Gunmadai I Shinkeiseishin'igaku)
YONEMURA KIMIE
(Gunmadai I Shinkeiseishin'igaku)
FUKUDA MASATO
(Gunmadai I Shinkeiseishin'igaku)
ORIUCHI NOBORU
(Gunmadai I Kakuigaku)
INOUE TOMIO
(Gunmadai I Kakuigaku)
MATSUDA HIROSHI
(Kokuritsuseishinshinkeise Hoshasenshinryobu)
MIKUNI MASAHIKO
(Gunmadai I Shinkeiseishin'igaku)
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Journal Title;Annual Report of the Pharmacopsychiatry Research Foundation
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Journal Code:Y0939A
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ISSN:0286-7591
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VOL.;NO.34;PAGE.72-77(2002)
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| Figure&Table&Reference;FIG.3, REF.15 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The authors investigated dexamethasone/corticotropin-releasing hormone(DEX/CRH) challenge test and [18F] FDG-PET in cases of depression. Twenty four patients, who met the DSM-IV criteria for major depressive episode in the context of major depressive disorder and were free from medication with antidepressants were recruited. They were performed DEX/CRH test and [18F] FDG-PET at a same period. Among of them, 10 patients who were recognized as responders were received DEX/CRH test and [18F] FDG-PET once more. In the DEX/CRH test, a normal plasma cortisol concentrations under such test conditions was commonly set at 50ng/ml or below. Seventy % of 10 pretreatment patients(7 patients) were recognized as nonsuppressors(.GEQ.50ng/ml). After medicated, the nonsupressors decreased to 20% (2 patients) and the degree of increase of the level posttreatment was lower than that before. On the PET, frontal gyri and temporal gyri, those were decreased metabolisms in pretreatment and limbic areas those were increased in pretreatment almost improved in posttreatment. Moreover, to compare 18 nonsuppressors to 6 suppressors(in 24 patients), there were the decreased metabolism in frontal gyri and limbic areas. In summary, it is recognized that the frontal gyri and limbic areas are reciprocally associated with the pathophysiology of depression. (author abst.) |
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