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Accession number;02A0472877
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| Title;[11C](+)McN5652 binding in patients with mood disorders. |
| Author;
ICHIMIYA TETSUYA
(National Inst. Radiological Sciences)
SUHARA TETSUYA
(National Inst. Radiological Sciences)
SUDO YASUHIKO
(National Inst. Radiological Sciences)
INOUE MAKOTO
(National Inst. Radiological Sciences)
YASUNO FUMIHIKO
(National Inst. Radiological Sciences)
TAKANO AKIHIRO
(National Inst. Radiological Sciences)
OKUBO YOSHIRO
(National Inst. Radiological Sciences)
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Journal Title;Annual Report of the Pharmacopsychiatry Research Foundation
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Journal Code:Y0939A
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ISSN:0286-7591
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VOL.;NO.34;PAGE.78-83(2002)
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| Figure&Table&Reference;FIG.1, TBL.1, REF.21 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Rationale: Several lines of studies have suggested the involvement of serotonin transporter(5-HTT) in the pathophysiology of mood disorders. [11C](+)McN5652 has a selective and high affinity for 5-HTT, and can be used for quantification of 5-HTT binding. Objectives: The aim of this study was to examine whether 5-HTT binding was altered in patients with mood disorders using positron emission tomography(PET). Methods: Thirteen antidepressant-naive or -free patients with mood disorders and 21 age-matched healthy controls participated in this study. The patients consisted of 7 with major depressive disorder (MDD) and 6 with bipolar disorder(BD). Binding potential(BP) was estimated in the thalamus and midbrain using a graphical method with the cerebellum as a reference tissue. Results: BP in the thalamus was significantly increased in patients with mood disorders as compared with controls, while BP in the midbrain did not differ between the groups. Subgroup comparison showed that MDD patients had significantly higher BP in the thalamus compared to controls. Conclusions: These findings suggest the possibility of altered 5-HTT in patients with mood disorders. Functional abnormality in the thalamus may be involved in the pathophysiology of mood disorders. (author abst.) |
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