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Accession number;02A0472882
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| Title;Effect of risperidone on methamphetamine psychosis. |
| Author;
AKIYAMA KAZUFUMI
(Dokkyoidai Seishinshinkeiigaku)
ISAO TAKETO
(Dokkyoidai Seishinshinkeiigaku)
ONO SANAE
(Tochigikeimusho)
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Journal Title;Annual Report of the Pharmacopsychiatry Research Foundation
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Journal Code:Y0939A
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ISSN:0286-7591
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VOL.;NO.34;PAGE.111-116(2002)
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| Figure&Table&Reference;FIG.2, TBL.1, REF.10 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The present study investigated therapeutic effect of risperidone on psychotic symptoms of 13 patients(5 male and 8 female) with methamphetamine(METH) psychosis who were jailed. The patients were referred for psychiatric consultation due to protracted psychosis or spontaneous relapse after abstinence period of 2 years and 2 months on an average since their last METH injection. The subjects received medication with either haloperidol (7 cases; 3 male and 4 female) or risperidone (6 cases;2 male and 4 female) at first in an attempt to compare benefit of both neuroleptics. Medication with haloperidol resulted in insufficient improvement of psychotic symptoms and/or occurrence of extrapyramidal symptoms. Haloperidol was replaced by risperidone in all such subjects. The patients who continued to receive risperidone since entry of the study tolerated minor extrapyramidal symptoms which eventually vanished. Eight female patients were subject to measurement of psychotic symptoms using Brief Psychiatric Rating Scale(BPRS). Clinical improvement of the BPRS scores was achieved at week 20 in five patients (four treated continuously with risperidone and one treated with haloperidol and subsequently risperidone). However, three patients who were treated with haloperidol and subsequently risperidone suffered from persistent paranoid-hallucinatory symptoms associated with depressive mood and exhibited akathisia and Parkinsonism. (author abst.) |
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