Memantine, but not bromocriptine, prevents the development of hyperthermia in an animal model of the serotonin syndrome.
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Accession number;02A0472883
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| Title;Memantine, but not bromocriptine, prevents the development of hyperthermia in an animal model of the serotonin syndrome. |
| Author;
NISHIJIMA KOICHI
(Jichiidai Seishin'igaku)
YOSHINO TATSUKI
(Jichiidai Yakuzaibu)
NIBUYA MASASHI
(Jichiidai Seishin'igaku)
YUI KUNIO
(Jichiidai Seishin'igaku)
KATO SATOSHI
(Jichiidai Seishin'igaku)
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Journal Title;Annual Report of the Pharmacopsychiatry Research Foundation
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Journal Code:Y0939A
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ISSN:0286-7591
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VOL.;NO.34;PAGE.117-124(2002)
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| Figure&Table&Reference;FIG.8, TBL.1, REF.11 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;In the present study, the effects of dopamine agonists including bromocriptine and memantine on an animal model of the serotonin(5-HT) syndrome were evaluated. When 2mg/kg of clorgyline, a type-A monoamine oxidase inhibiting antidepressant, and 100mg/kg of 5-hydroxy-L-tryptophan(5-HTP), a precursor of 5-HT, were administered intraperitoneally(i.p.) to rats to induce the 5-HT syndrome, the rectal temperature of the rats increased to more than 40.DEG.C., and all of the animals died by 90 min after the drug administration. The noradrenaline(NA) and 5-HT in the anterior hypothalamus were measured every 15 min by microdialysis. The NA and 5-HT levels increased to about 15 and 1000-fold the preadministration level, respectively. Pretreatment with bromocriptine(10mg/kg and 20mg/kg, i.p.) could not prevent the development of hyperthermia and the increase of NA level. Memantine, a dopamine agonist as well as a NMDA receptor antagonist, prevented the development of hyperthermia and the increase of NA level. MK-801 (0.5mg/kg, i.p.), a NMDA receptor antagonist, also prevented the development of hyperthermia. These results suggest that the efficacy of memantine on inhibiting the development of hyperthermia in an animal model of 5-HT syndrome is due to NMDA receptor blocking effect. (author abst.) |
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