Effects of the adenosine A1 receptor agonist N6-cyclopentyladenosine on phencyclidine-induced expression of immediate-early genes in the rat brain.

Accession number;02A0472887
Title;Effects of the adenosine A1 receptor agonist N6-cyclopentyladenosine on phencyclidine-induced expression of immediate-early genes in the rat brain.
Author; UCHIMURA HIDEYUKI (Kokuritsuhizenryoyosho Jodokodoshogaise) HONDO HISAO (Kokuritsuhizenryoyosho Jodokodoshogaise) MOTOMURA KEISUKE (Kokuritsuhizenryoyosho Jodokodoshogaise) UEKI HIROSHI (Kokuritsuhizenryoyosho Jodokodoshogaise) HASHIMOTO KIJIRO (Kokuritsuhizenryoyosho Jodokodoshogaise) NAKANE HIDEYUKI (Kokuritsuhizenryoyosho Jodokodoshogaise) TSUTSUMI TETSUYUKI (Kokuritsuhizenryoyosho Jodokodoshogaise) YUZURIHA TAKEFUMI (Kokuritsuhizenryoyosho Jodokodoshogaise) NAKAHARA TATSUO (Kyudai Daigakuinrigakukenkyuin Kagaku)
Journal Title;Annual Report of the Pharmacopsychiatry Research Foundation
Journal Code:Y0939A
ISSN:0286-7591
VOL.;NO.34;PAGE.146-154(2002)
Figure&Table&Reference;FIG.5, REF.30
Pub. Country;Japan
Language;Japanese
Abstract;Because of the possible interaction between adenosine receptors and dopaminergic functions, the compound acting on the specific adenosine receptor subtype may be a candidate for novel antipsychotic drugs. To elucidate the antipsychotic potential of the selective adenosine A1 receptor agonist N6-cyclopentyladenosine(CPA), we examined herein the effects of CPA on phencyclidine(PCP)-induced behavior and expression of the immediate-early genes, arc, c-fos and jun B, in the discrete brain regions of rats. PCP(7.5mg/kg, s.c.) increased locomotor activity and head weaving in rats, and this effect was significantly attenuated by pretreatment with CPA(0.5mg/kg, s.c.). PCP increased the levels of arc, c-fos and jun B mRNAs in the medial prefrontal cortex and posterior cingulate cortex, c-fos and jun B mRNA levels in the nucleus accumbens core and decreased arc mRNA levels in the striatum without affecting all genes tested in the hippocampus. CPA pretreatment significantly attenuated the PCP-induced arc, c-fos and jun B expression in the medial prefrontal cortex. CPA also significantly decreased the PCP-induced increase in c-fos mRNA levels in the medial prefrontal cortex and nucleus accumbens. Since the atypical antipsychotic clozapine, risperidone and olanzapine, but not the typical antipsychotic haloperidol, have been reported to attenuate the PCP-induced arc expression in the medial prefrontal cortex, the present results suggest an atypical antipsychotic profile of the adenosine A1 agonist. (author abst.)
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