|
Accession number;02A0472888
|
| Title;Effect of Diazepam, Risperidon, Fluvoxzmine on phencyclidine-induced social behavior deficit in mice. |
| Author;
KYO HIROSHI
(Nagoyadai Daigakuin'igakukenkyuka Seishin'igaku)
NODA YUKIHIRO
(Nagoya Univ.)
MIURA HIDEKI
(Nagoyadai Daigakuin'igakukenkyuka Seishin'igaku)
NABESHIMA TOSHITAKA
(Nagoya Univ.)
OTA TATSURO
(Nagoyadai Daigakuin'igakukenkyuka Seishin'igaku)
|
Journal Title;Annual Report of the Pharmacopsychiatry Research Foundation
|
Journal Code:Y0939A
|
ISSN:0286-7591
|
|
VOL.;NO.34;PAGE.155-160(2002)
|
| Figure&Table&Reference;FIG.3, REF.26 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Phencyclidine(PCP) can induce that mimics the positive and negative symptoms of schizophrenia in humans. The social behavior deficit in mice was produced by treatment with PCP(10mg/kg/day) for 14 days, which persisted for 4 weeks after withdrawal. In the present study, effect of several antipsychotic on PCP reduced social behavior deficit in a dose and time dependent fashion in mice. The social behavior deficit by treatment with PCP (10mg/kg/day) for 14 days was attenuated by rispridone (1mg/kg/day) given for 7 days, whereas diazepam or low-dose risperidone (0.5mg/kg/day) for 7 days had no effect. Fluvoxamine (30mg/kg/day), alone at the same treatment dose increased social behavior in PCP-treated mice. These results suggest that the proposed PCP model in mice will provide a tool to test beneficial effects of atypical antipsychotics on social dysfunction in schizophrenia, and contribute to our understanding of the mechanisms by which risperidone or fluvoxamine improves social behavior deficit. (author abst.) |
|
|
|
Related Articles;
|
