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Accession number;02A0472889
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| Title;The distribution of serotonin transpoter immunoreactivity in the hippocampal formation of schizophrenic brain. |
| Author;
MATSUSHITA MASAAKI
(Tokyotomatsuzawabyoin Seishinka)
IRITANI SHUJI
(Tokyotomatsuzawabyoin Seishinka)
OWASHI TOSHIMI
(Tokyotomatsuzawabyoin Seishinka)
NIIZATO KAZUHIRO
(Tokyotomatsuzawabyoin Seishinka)
NAKAMURA RYOSUKE
(Tokyotomatsuzawabyoin Seishinka)
UENO HIDEKI
(Tokyotomatsuzawabyoin Seishinka)
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Journal Title;Annual Report of the Pharmacopsychiatry Research Foundation
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Journal Code:Y0939A
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ISSN:0286-7591
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VOL.;NO.34;PAGE.161-167(2002)
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| Figure&Table&Reference;FIG.4, REF.29 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Recent studies have demonstrated the involvement of serotonergic neurotransmitter systems in several psychiatric disorders include schizophrenia. To elucidate the anatomical function of this system, we used immunohistochemical techniques to examine the distribution of the serotonin transporter(5-HTT) in the hippocampus of rats, monkeys, and humans including schizophrenic subjects. As the results, a widespread and heterogeneous distribution of the 5-HTT immunoreactive fine fibers was observed in the stratum(st.) moleculare of dentate gyrus, in the st. oriens of CA1 and the st. lacunosum molecular and st. radiatum of CA1-CA3 regions of the hippocampus in rat brain. For humans and monkeys, marked amounts of 5-HTT immunoreactive deposits and lesser fibers were observed in st. moleculare of dentate gyrus, in the st. lucidum of CA3, st. radiatum of CA1-CA3 regions of the hippocampus and in subiculum compared to those in the rat brain. The pyramidal cell bodies of st. pyramidale were slightly immunoreacted. These observations suggest that the role of 5-HTT may differ between species and concern higher mental function. These findings also suggest that 5-HTT may be preferentially sorted into axons, where it appears concentrated at varicosities and terminal boutons. In the subjects with schizophrenia, 5-HTT-immunoreactive deposits were reduced throughout the CA fields compared to those in the normal control cases. This reduction of 5-HTT in the hippocampus might contribute to the pathphysiological process in the schizophrenic brain. (author abst.) |
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