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Accession number;02A0472893
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| Title;Study on the molecular mechanism of D-serine metabolism and its application for the development of novel anti-schizophrenic drugs. |
| Author;
YAMAMOTO NAOKI
(Natl. Inst. of Neurosci.)
TSUCHIDA HIDETO
(Natl. Inst. of Neurosci.)
UMINO ASAMI
(Natl. Inst. of Neurosci.)
KAJII YASUSHI
(Natl. Inst. of Neurosci.)
IWAMA HISAYUKI
(Natl. Inst. of Neurosci.)
MURAOKA SHIN'ICHIRO
(Natl. Inst. of Neurosci.)
SAKURAI SHIN'ICHIRO
(Natl. Inst. of Neurosci.)
SHIMAZU DAI
(Natl. Inst. of Neurosci.)
NISHIKAWA TOORU
(Natl. Inst. of Neurosci.)
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Journal Title;Annual Report of the Pharmacopsychiatry Research Foundation
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Journal Code:Y0939A
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ISSN:0286-7591
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VOL.;NO.34;PAGE.185-192(2002)
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| Figure&Table&Reference;FIG.3, REF.21 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;D-serine is an endogenous neuromodulator of glutamatergic signal in the mammalian central nervous system. To obtain insight into the molecular pathways for D-serine metabolism and physiological functions, we have explored transcripts that are responsive to D-serine in the rat cerebral neocortex. RNA arbitrary primed PCR(RAP-PCR), a differential cloning method, was utilized in the present study. We have isolated a D-serine-regulated transcript, dsr-1. The dsr-1 was expressed predominantly in the brain, lung, and testis. The expression of dsr-1 is selectively regulated by D-serine in the brain. The present results suggest that dsr-1 products may play a crucial role in the regulation of D-serine metabolism as well as in the maintenance and activation of vesicles in the central nervous system. Characterization of dsr-1 and other D-serine-regulated gene products may enable us to further understand the mechanism of D-serine metabolism and to develop novel antipsychotic drugs that regulate glutamatergic signaling through the endogenous D-serine action. (author abst.) |
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