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Accession number;02A0472894
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| Title;The mechanism of intracytoplasmic aggregation of tau protein in neurodegenerative diseases. |
| Author;
ARAI TETSUAKI
(Psychiatr. Res. Inst. of Tokyo)
AKIYAMA HARUHIKO
(Psychiatr. Res. Inst. of Tokyo)
IKEDA KENJI
(Psychiatr. Res. Inst. of Tokyo)
MATSUSHITA MASAAKI
(Psychiatr. Res. Inst. of Tokyo)
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Journal Title;Annual Report of the Pharmacopsychiatry Research Foundation
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Journal Code:Y0939A
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ISSN:0286-7591
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VOL.;NO.34;PAGE.193-199(2002)
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| Figure&Table&Reference;FIG.6, REF.16 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The microtubule-associated protein tau aggregates as cytoplasmic inclusions not only in neurons but also in glial cells in a variety of neurodegenerative diseases. The primary cultured rat astrocytes were treated with protease inhibitors to investigate whether the failure of tau metabolism is related to tau aggregates in glial cells. Lysosomal protease inhibitors, chloroquine and leupeptin, induced tau accumulation in the cytoplasm of the cells, as observed by immunocytochemistry and immunoelectron microscopy. Immunoblot analysis of cell extracts showed that leupeptin treatment markedly enhanced the immunoreactivity of several low molecular weight tau fragments that may be incomplete degradation products. These results suggest that lysosomal dysfunction affects degradation of tau, resulting in intracytoplasmic tau accumulation in astrocytes. (author abst.) |
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