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Accession number;02A0472901
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| Title;Association Study between a Functional Monoamine Oxidase A Gene Polymorphism and Completed Suicides. |
| Author;
ONO HISAE
(Kobedai Daigakuin'igakukeikenkyuka Seishinshinkeika)
SHIRAKAWA OSAMU
(Kobedai Daigakuin'igakukeikenkyuka Seishinshinkeika)
NISHIMURA AKIYOSHI
(Yokohamashidai I Hoigaku)
NUSHIDA HIDEYUKI
(Kobedai Daigakuin'igakukeikenkyuka Hoigaku)
UENO YASUHIRO
(Kobedai Daigakuin'igakukeikenkyuka Hoigaku)
MAEDA KIYOSHI
(Kobedai Daigakuin'igakukeikenkyuka Seishinshinkeika)
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Journal Title;Annual Report of the Pharmacopsychiatry Research Foundation
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Journal Code:Y0939A
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ISSN:0286-7591
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VOL.;NO.34;PAGE.242-247(2002)
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| Figure&Table&Reference;TBL.3, REF.22 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Biochemical studies have suggested that dysfunction in monoamine neurotransmissions is associated with suicide. Monoamine Oxidase A(MAOA) is one of the major enzymes responsible for the degradation of neurotransmitters such as noradrenaline, dopamine and serotonin. There have been several lines of evidence suggesting that MAOA has been implicated in the control of aggression and/or impulsivity in humans, and to be involved in suicide. This gene has a functional polymorphism in which there is a variable number tandem repeat(VNTR) in the upstream region(MAOA-uVNTR). We hypothesized that MAOA dysfunction due to this polymorphism was associated with suicide genetically through the disinhibition of aggression and/or impulsivity. We performed an association study between completed suicides and the MAOA-uVNTR polymorphism. No significant difference in genotype distribution or allele frequencies was found between completed suicides and comparison groups either in males or females. These results show no evidence of an association between the MAOA-uVNTR polymorphism and completed suicides, and suggest that MAOA is not involved in the susceptibility to suicide. (author abst.) |
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