|
Accession number;02A0472902
|
| Title;The impact of CYP2D*5 allele on haloperidol metabolism in a Japanese psychiatric population. |
| Author;
SUZUKI YUTARO
(Niigatadai Daigakuin'ishigakusogokenkyuuka Seishin'igaku)
SAWAMURA KAZUSHI
(Niigatadai Daigakuin'ishigakusogokenkyuuka Seishin'igaku)
SATO SATOSHI
(Niigatadai Daigakuin'ishigakusogokenkyuuka Seishin'igaku)
KAWASHIMA YOSHIAKI
(Niigatadai Daigakuin'ishigakusogokenkyuuka Seishin'igaku)
SHIMODA KAZUTAKA
(Shigaidai I Seishin'igaku)
HIROKANE GENTA
(Niigatadai Daigakuin'ishigakusogokenkyuuka Seishin'igaku)
MORITA SACHIYO
(Shigaidai I Seishin'igaku)
INOUE YOSHIMASA
(Mitsubishiwerufama)
TAKAHASHI SABURO
(Jinwakai Saitama Konan Byoin)
|
Journal Title;Annual Report of the Pharmacopsychiatry Research Foundation
|
Journal Code:Y0939A
|
ISSN:0286-7591
|
|
VOL.;NO.34;PAGE.248-256(2002)
|
| Figure&Table&Reference;FIG.1, TBL.2, REF.28 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We investigated the effect of CYP2D6 genotypes(CYP2D6*1, CYP2D6*2, CYP2D6*5 and CYP2D6*10) on plasma levels of haloperidol(HAL) and reduced haloperidol(RHAL) in 89 Japanese schizophrenic inpatients being treated with HAL. Blood samples were categorized into three groups [all patients, patients with low HAL dose(<10mg/day), and high HAL dose(>10mg/day)] and analyzed since isozymes other than CYP2D6 are involved in HAL metabolism, with different doses may be leading to different contributions for each enzyme. We found: (1) The number of CYP2D6 mutated alleles did not significantly affect the plasma concentrations of HAL and RHAL in any group. (2) For the genotype of CYP2D6, the group with the CYP2D6*5 allele had significantly higher plasma concentrations of HAL and RHAL than the group without the CYP2D6*5 allele in all patients. This tendency was seen in the low dose samples, but not in the high dose samples. (3) The CYP2D6*2 allele did not significantly affect the plasma concentrations of HAL and RHAL. These results indicate that the impact of the *5 allele is most important, especially under low dose conditions, when considering the HAL metabolism in Asian populations, including Japanese. (author abst.) |
|
|
|
Related Articles;
|
